While CRNA wages differ from state to state, the national mean salary for a nurse anesthetist is $78.86 per hour, according to the Bureau of Labor Statistics (BLS). This equates to a mean annual salary of $164,030. CRNAs may also receive additional compensation through overtime, bonuses, and profit sharing, depending on their place of employment. Average Salary for CRNAs. Although nurse anesthetists earn an average salary of $195,610, their pay can be greatly influenced by a number of factors, including workplace, level of education, and experience. The top 10% of earners make more than $200,000 per year, according to the BLS.